This study evaluated the effects of dietary supplementation with Acanthopanax senticosus extract (ASW) on growth performance, lipid metabolism, antioxidant capacity and immune response of Yellow River carp (Cyprinus carpio). Five isonitrogenous and isolipidic diets were formulated with ASW inclusion levels of 0 (control), 0.3‰, 0.6‰, 0.9‰, and 1.2‰. The experimental fish (initial body weight: 68.27 ± 0.04 g) were fed these diets for 56d, with three replicates per group. While the growth performance of fish across all ASW supplementation groups showed no statistically significant differences, a trend of improved weight gain rate and feed conversion ratio was observed in the 0.3‰ – 0.6‰ groups compared to the higher-dose groups. Physiological and biochemical indicators showed that ASW supplementation significantly improved certain lipid metabolism parameters: serum triglyceride, total cholesterol, and low-density lipoprotein levels were significantly reduced in the 0.3‰ – 0.6‰ supplementation groups, while liver arachidonic acid, docosahexaenoic acid, and long-chain polyunsaturated fatty acid contents were highest in the 0.9‰ supplementation group . Intestinal lipase and amylase activities were significantly enhanced in the 0.3‰ – 0.6‰ supplementation groups. Regarding antioxidant capacity and immunity, compared with the control group, ASW supplementation groups showed increased total antioxidant capacity in serum and liver, as well as elevated liver catalase activity. The tissue antioxidant capacity was significantly improved in the 0.6‰ supplementation group; liver acid phosphatase and alkaline phosphatase activities also increased significantly in the 0.3‰ supplementation group. Gene expression analysis indicated that the expression of lipid metabolism-related genes pparα, hnf4α, and elovl5 exhibited dose-dependent changes. In the 0.3‰ group, the expression of antioxidant- and inflammation-related genes nrf2 and ifn-γ was significantly upregulated, while keap1 and il-8 expression was downregulated. In conclusion, the addition of ASW at 0.3‰ to the diet demonstrated superior effects in improving blood lipid metabolism, enhancing non-specific immunity, and regulating immune-related gene expression in Yellow River carp.