The ingestion rates of Ruditapes philippinarum fed with Isochrysis galbana3011 under simulated conditions were studied. Moreover, investigation of the relationship between feed ingestion and temperature (12 ℃、20 ℃ and 24 ℃), shell length and algae concentration was carried out, and some mathematic models about the factors were set up. It was found that the ingestion rate was positively correlated with the algae concentration, and the ingestion rate of Ruditapes philippinarum correlated with them by the allometric equations. The impact of temperature, shell length and algae concentration on ingestion rate could be described by the following model: IR=21.2LnT+20.06LnL 7.10LnC-97.95, and analysis of covariance showed that the coefficient of correlation of the model was significant (P<0.01)